Nurse Betty

Renée Zellweger

Betty Sizemore

Morgan Freeman

Charlie

Chris Rock

Wesley

Greg Kinnear

Dr. David Ravell/George McCord

Aaron Eckhart

Del Sizemore

Tia Texada

Rosa Hernandez

Crispin Glover

Roy Ostery

Pruitt Taylor Vince

Ballard

Allison Janney

Lyla Branch

Kathleen Wilhoite

Sue Ann Rogers

Elizabeth Mitchell

Chloe Jensen

Susan Barnes

Darlene

Harriet Sansom Harris

Ellen

Sung-Hi Lee

Jasmine

Laird Macintosh

Dr. Lonnie Walsh

Steven Gilborn

Blake

Jenny Gago

Mercedes

Sheila Kelley

Joyce

Matthew Cowles

Merle

Wayne Tippit

Doctor

George Wallace

Grandfather

Lesley Woods

Grandmother

Cynthia Martells

Chief Nurse

Alfonso Freeman

ER Doctor

Kevin Rahm

Friend #1

Steven Culp

Friend #2

Deborah May

Gloria Walsh

Max Murphy

Studio Guard

Tina Smith

Waitress

T.J. Kennedy

Cook

Irene Olga López

Rosa's Mother

Steve Franken

Administrator

Kelwin Hagen

Deputy

Josh Dotson

Parking Valet

Dona Hardy

Woman Patient

José Vásquez

Gang Member

Elaine Corral Kendall

Anchor

Greg Bronson

Diner Patron (non-crédité)

Rebeca Cristian

Hospital Patient (non-crédité)

Michelle Carmen Gomez

Woman at Bar (non-crédité)

Toby Linz

Sue Ann's Son (non-crédité)

Hillary Straney

Woman in Hotel (non-crédité)

Jenny Wade

Diner Waitress (non-crédité)