O'Brother

George Clooney

Ulysses Everett McGill

John Turturro

Pete Hogwallop

Tim Blake Nelson

Delmar O'Donnell

Chris Thomas King

Tommy Johnson

John Goodman

Daniel 'Big Dan' Teague

Holly Hunter

Penny Wharvey-McGill

Frank Collison

Washington B. 'Wash' Hogwallop

Charles Durning

Menelaus 'Pappy' O'Daniel

Daniel von Bargen

Sheriff Cooley

Wayne Duvall

Homer Stokes

Ray McKinnon

Vernon T. Waldrip

Stephen Root

Mr. Lund

Del Pentecost

Junior O'Daniel

Michael Badalucco

George 'Baby Face' Nelson

Musetta Vander

Siren

Mia Tate

Siren

Christy Taylor

Siren

Lee Weaver

Blind Seer

J.R. Horne

Pappy's Staff

Brian Reddy

Pappy's Staff

Ed Gale

The Little Man

Millford Fortenberry

Pomade Vendor

Quinn Gasaway

Boy Hogwallop

Royce D. Applegate

Man with Bullhorn