Pootie Tang

Lance Crouther

Pootie Tang

Jennifer Coolidge

Ireenie

J.B. Smoove

Trucky

Reg E. Cathey

Dirty Dee

Robert Vaughn

Dick Lecter

Wanda Sykes

Biggie Shorty

Chris Rock

JB / Radio DJ / Pootie's Father

Mario Joyner

Lacey

Cathy Trien

Stacy

Laura Kightlinger

Anchor Woman

Dave Attell

Frank

Rick Shapiro

Shakey

Christopher Wynkoop

Sheriff

J.D. Williams

Froggy

Missy Elliott

Diva

David Cross

Dennis

Qiana Drew

Singing Lady

Lorria Richards

Singing Lady

Andy Richter

Record Executive

Kristen Bell

Record Executive's Daughter

Cole Hawkins

Little Pootie

Tara Jeffers

Solo Girl Singer

Conan O'Brien

Conan O’Brien (non-crédité)

Ebony Jo-Ann

Pootie's Mother